Processivity and fatty acid oxidation.

446 TDRAs, through the partial and group response coefficients, confirm that, under every condition that we have studied, malonyl-CoA exerts its effects over the pathway via CPT I. These conclusions apply only to our system and our conditions. Yet our TDCAs in a more physiological system, including ketone body and ATP synthesis in coupled mitochondria, show that in state 3 CPT I has most of the control and in states intermediate between 3 and 4 the control is shared. That the simple TDCAs show most of the control resides with the P-oxidation block is potentially misleading, as the TDRAs show malonyl-CoA regulates the pathway via its effects on CPT I.